Therapeutic efficacy as predicted by quantitative assessment of murine RIF-1 tumour pH and phosphorous metabolite response during hyperthermia:: an in vivo 31P NMR study
Therapeutic efficacy as predicted by quantitative assessment of murine RIF-1 tumour pH and phosphorous metabolite response during hyperthermia:: an in vivo 31P NMR study
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DOI：
10.1080/0265673042000196469
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发表时间：
2004-06-01
影响因子：
3.1
通讯作者：
Ackerman, JJH
中科院分区：
文献类型：
--
作者：
Bezabeh, T;Evelhoch, JL;Ackerman, JJH
本文描述的是“磁内”P-31核磁共振兼容热疗系统的初步发现，该系统能够同时加热和监测小鼠肿瘤的代谢反应；本研究采用小鼠辐射诱导纤维肉瘤（RIF-1）。在加热剂量足以将肿瘤温度提高到41.5度和43度，持续30分钟时，观察到三磷酸核苷浓度和pH值在加热期间显着而迅速下降，而无机磷酸盐浓度显著增加，但更缓慢。这些P-31核磁共振测定的代谢指标在热疗监测后的1.5小时内保持降低/升高。重要的是，这些代谢指标与特定生长延迟显著相关。这表明核磁共振波谱在热疗治疗反应的早期评估和控制中可能发挥作用。
Described herein are the initial findings from an 'in-magnet' P-31 NMR compatible hyperthermia system capable of concurrently heating and monitoring the metabolic response of murine tumours; the murine radiation induced fibrosarcoma (RIF-1) was employed for these studies. At thermal doses sufficient to raise tumour temperature to 41.5 and 43degreesC for a period of 30 min, a marked and rapid decrease in nucleoside triphosphate concentration and in pH was observed during the heating period, while inorganic phosphate concentration increased significantly but more gradually. These P-31 NMR determined metabolic indices remained depressed/elevated throughout a 1.5 h post-hyperthermia monitoring period. Importantly, these metabolic indices correlated significantly with specific growth delay. This suggests a possible role for NMR spectroscopy in early assessment, and perhaps control, of therapeutic response to hyperthermia.