Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging
Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging
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DOI：
10.1016/j.nano.2012.11.009
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发表时间：
2013-07-01
影响因子：
5.4
通讯作者：
Batt, Carl A.
中科院分区：
文献类型：
--
作者：
Kirui, Dickson K.;Khalidov, Ildar;Batt, Carl A.
我们报告了免疫靶向的金-氧化铁杂化纳米颗粒用于激光辅助治疗和基于MRI的成像，如在异种结直肠癌肿瘤模型中所展示的那样。与非抗原表达的肿瘤移植瘤相比，免疫靶向的金氧化铁纳米颗粒选择性地在SW1222移植瘤中积聚。应用近红外激光(808 nm，5W cm(-2))进行有效的光热治疗，其中65%的表达抗原的肿瘤细胞呈现破坏的细胞外基质和胞浆嗜酸性，这表明纳米颗粒辅助热疗是有效的。苏木精-伊红(H&E)组织学染色证实细胞杀伤作用，治疗组可见含有胶原束的瘢痕样结构。此外，系统注射的HNPs被证明是有效的T-2磁共振(MR)造影剂，定位并检测到抗原表达的异种移植瘤。这些发现表明，新型生物偶联HNPs在双重治疗和诊断(治疗)应用方面显示出巨大的潜力。来自《临床编辑》：该团队报道了免疫靶向的金-氧化铁复合纳米颗粒在异种结直肠癌肿瘤模型中成功地用于激光辅助治疗和基于MRI的成像，展示了在癌症诊断和治疗中的双重应用的强大潜力。(C)2013 Elsevier Inc.保留所有权利。
We report the use of immuno-targeted gold-iron oxide hybrid nanoparticles for laser-assisted therapy and for MRI-based imaging as demonstrated in xenograft colorectal cancer tumor model. Immuno-targeted gold-iron oxide nanoparticles selectively accumulate in SW1222 xenograft tumors as compared to the accumulation in non-antigen-expressing tumor xenografts. Effective photothermal treatment using near-IR laser irradiation (808 nm, 5 W cm(-2)) application is shown where >65% of the antigen-expressing tumor cells presented corrupt extracellular matrix and cytoplasmic acidophilia suggesting effectiveness of nanoparticle-assisted thermal therapy. Cell killing was confirmed by hematoxylin and eosin (H&E) histological staining where scar-like structure containing collagen bundles was observed in the treatment group. Further, systemically injected HNPs were shown to be effective T-2 magnetic resonance (MR) imaging contrast agents, localized and detected at the antigen-expressing xenograft tumors. These findings suggest that the new class of bio-conjugated HNPs exhibits great potential for dual-therapy and diagnostics (theranostics) applications. From the Clinical Editor: This team reports the successful use of immuno-targeted gold-iron oxide hybrid nanoparticles for both laser-assisted therapy and MRI-based imaging in a xenograft colorectal cancer tumor model, demonstrating strong potentials for dual applications in cancer diagnosis and therapy. (C) 2013 Elsevier Inc. All rights reserved.