THE SCID-HU MOUSE - MURINE MODEL FOR THE ANALYSIS OF HUMAN HEMATOLYMPHOID DIFFERENTIATION AND FUNCTION
THE SCID-HU MOUSE - MURINE MODEL FOR THE ANALYSIS OF HUMAN HEMATOLYMPHOID DIFFERENTIATION AND FUNCTION
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DOI：
10.1126/science.2971269
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发表时间：
1988-09-23
期刊：
影响因子：
56.9
通讯作者：
WEISSMAN, IL
中科院分区：
文献类型：
--
作者：
MCCUNE, JM;NAMIKAWA, R;WEISSMAN, IL
人类造血细胞和人类免疫系统的研究由于缺乏合适的实验模型而受到阻碍。实验数据显示，人胎儿肝脏造血细胞、人胎儿胸腺和人胎儿淋巴结在移植到遗传决定的严重联合免疫缺陷小鼠体内后，支持成熟的人T细胞和B细胞的分化。由此产生的SCID-hu小鼠外周循环中存在人CD4+和CD8+ T细胞和人IgG（免疫球蛋白G）的瞬态波。在这种小鼠模型中，人类免疫系统的功能状态尚不清楚。
The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.