Feeding effects on growth during infancy
Feeding effects on growth during infancy
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DOI：
10.1016/j.jpeds.2004.06.069
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Dewey, K
中科院分区：
文献类型：
--
作者：
Kramer, MS;Guo, T;Dewey, K
目的探讨配方奶粉、其他牛奶、其他液体、谷物和其他固体食物对婴儿生长发育的影响。研究设计观察性队列研究嵌套在一项大型（n = 17046）聚类随机试验中。我们比较了婴儿在1至3个月、3至6个月、6至9个月和9至12个月期间的生长[年龄体重、年龄长度和体重长度z分数（WAZ、LAZ、WLZ）和头围（HC）]，使用分层多元回归来控制每个区间开始时的大小、母亲教育程度、地理区域和城市与农村位置。结果混合BF和配方奶/其他奶在1至3个月时的LAZ显著高于纯母乳（分别为+0.038和+0.047）。在3至6个月的时间间隔内，混合BF和配方奶/其他奶显著提高了WAZ（+0.125和+0.139）和LAZ(+0.081和+0.075)，而谷物摄入与两项测量（-0.293和-0.240）和HC （-0.291 cm）的大幅和高度显著降低相关。在6- 9个月和9- 12个月期间，混合BF和配方奶/其他奶继续与WAZ和LAZ呈正相关，但相关性较小。结论：我们的研究结果证实，配方奶和其他奶（相对于母乳）对婴儿体重和身高的增长有加速作用，在婴儿3至6个月时观察到剂量-反应梯度和最大的相关性。
Objective To examine the effects of formula, other milks, other liquids, cereals, and other solid foods on growth during infancy.Study design Observational cohort study nested within a large (n = 17,046), cluster-randomized trial. We compared growth [weight-for-age, length-for-age, and weight-for-length z scores (WAZ, LAZ, WLZ) and head circumference (HC)] during the intervals 1 to 3, 3 to 6, 6 to 9, and 9 to 12 months, using hierarchical multivariate regression to control for size at the beginning of each interval, maternal education, geographic region, and urban versus rural location.Results Mixed BF and formula/other milk were associated with significantly higher (versus breast milk only) LAZ at I to 3 months (+0.038 and +0.047, respectively). In the 3- to 6-month interval, mixed BF and formula/other milk led to significantly higher WAZ (+0.125 and +0.139) and LAZ (+0.081 and +0.075), whereas cereal intake was associated with large and highly significant reductions in both measures (-0.293 and -0.240) and in HC (-0.291 cm)., Mixed BF and formula/other milk continued to have positive albeit smaller associations with WAZ and LAZ in the 6- to 9-month and 9- to 12-month intervals.Conclusions Our results confirm the growth-accelerating effects of formula and other milks (versus breast milk) on weight and length gain throughout infancy, with a dose-response gradient and largest associations observed at 3 to 6 months.