Transition zone prostate cancer:: Metabolic characteristics at 1H MR spectroscopic imaging -: Initial results
Transition zone prostate cancer:: Metabolic characteristics at 1H MR spectroscopic imaging -: Initial results
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DOI：
10.1148/radiol.2291021383
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发表时间：
2003-10-01
期刊：
影响因子：
19.7
通讯作者：
Koutcher, JA
中科院分区：
文献类型：
--
作者：
Zakian, KL;Eberhardt, S;Koutcher, JA
目的：探讨前列腺移行区(TZ)肿瘤是否具有独特的代谢模式。材料与方法：回顾分析40例前列腺癌根治术前行直肠内MR和氢1磁共振波谱成像，并经分段病理分析确诊为TZ肿瘤患者的临床资料。在这一人群中，确定了16名患者的子集，他们的TZ肿瘤最大直径为1厘米或更大，并包括在MR光谱成像激发体积中。比较16例患者肿瘤组织和对照组织中胆碱类化合物(Cho)和肌酸/磷酸肌酸(Cr)/柠檬酸(Cit)的比值(即[Cho+Cr]/Cit)、Cho/Cr和Cho/Cit。结果：(Cho+Cr)/Cit、Cho/Cr和Cho/Cit在TZ癌组织和对照组织中的平均值有差异(分别为P=.001、P=.003和P=.001，Wilcoxon符号秩次检验)。在16例患者中，9例(56%)至少有一个肿瘤体素，其中Cho是唯一可检测到的峰，而没有对照体素仅显示Cho(P=0.008，McNemar检验)。未检测到代谢物的体素在肿瘤组织和对照组织中的百分比没有差异(P=.134，McNemar检验)。结论：TZ癌的代谢特征与良性TZ组织不同，但TZ癌中观察到的广泛代谢物比率排除了使用单一比率来区分TZ癌和良性TZ组织的可能性。(C)RSNA，2003年。
PURPOSE: To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging.MATERIALS AND METHODS: Findings in 40 patients who underwent combined endorectal MR imaging and hydrogen 1 MR spectroscopic imaging before radical prostatectomy and who had TZ tumor identified subsequently at step-section pathologic analysis were retrospectively reviewed. Within this population, a subset of 16 patients whose TZ tumor had a largest diameter of I cm or greater and was included in the MR spectroscopic imaging excitation volume was identified. In these 16 patients, the ratios of choline-containing compounds (Cho) and creatine/phosphocreatine (Cr) to citrate (Cit) (ie, [Cho + Cr]/Cit), Cho/Cr, and Cho/Cit were compared in tumor and control tissues. The presence of only Cho and the absence of all metabolites were also assessed.RESULTS: The mean values of (Cho + Cr)/Cit, Cho/Cr, and Cho/Cit were different between TZ cancer and control tissues (P = .001, P = .003, and P = .001, respectively, Wilcoxon signed rank test). Nine (56%) of 16 patients had at least one tumor voxel in which Cho comprised the only detectable peak, while no control voxels showed only Cho (P = .008, McNemar test). The percentage of voxels in which no metabolites were detected did not differ between tumor and control tissues (P = .134, McNemar test).CONCLUSION: TZ cancer has a metabolic profile that is different from that of benign TZ tissue; however, the broad range of metabolite ratios observed in TZ cancer precludes the use of a single ratio to differentiate TZ cancer from benign TZ tissue. (C) RSNA, 2003.