Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma
Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma
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DOI：
10.1038/eye.2010.139
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发表时间：
2011-01-01
期刊：
影响因子：
3.9
通讯作者：
Hollo, G.
中科院分区：
文献类型：
--
作者：
Garas, A.;Vargha, P.;Hollo, G.
目的评价RTVue-100型傅里叶域光学相干断层扫描（OCT）对白种人青光眼的诊断准确性，包括视网膜神经纤维层厚度（RNFLT）、神经节细胞复合体（GCC）和视盘测量。方法对286例白种人患者（健康眼93例，高眼压眼36例，周围型青光眼46例，周围型青光眼111例）随机选取一只眼进行评价。结果采用软件分类，对视神经头参数的总体敏感性不超过73.6%，对其他参数的敏感性不超过62.7%。大多数RNFLT和GCC参数特异性高（94.6-100%），但视盘参数特异性低（72.0-76.3%）。RNFLT主要参数的阳性预测值在98.1 ~ 100%之间，16个RNFLT扇区的阳性预测值在92.6 ~ 100%之间，GCC参数的阳性预测值在92.4 ~ 99.0%之间，但视盘参数的阳性预测值均未超过86.3%。平均、劣、优RNFLT（25.5 ~无穷大）、16个RNFLT扇区中的12个（12.6 ~无穷大）和4个GCC参数中的3个（40.0 ~ 48.6）的正似然比（PLR）均大于10。视盘各参数PLR均不高于3.0。结论RTVue-100傅里叶域OCT的RNFLT和GCC参数对青光眼的检测具有中等敏感性和高特异性，具有阳性的预测价值和PLR。视盘参数的诊断准确率低于RNFLT和GCC参数。眼科学（2011）25,57-65；doi: 10.1038 / eye.2010.139;2010年10月8日在线发布
Purpose To evaluate the diagnostic accuracy of retinal nerve fibre layer thickness (RNFLT), ganglion cell complex (GCC), and optic disc measurements made with the RTVue-100 Fourier-domain optical coherence tomography (OCT) to detect glaucoma in a Caucasian referral population.Methods One randomly selected eye of 286 Caucasian patients (93 healthy, 36 ocular hypertensive, 46 preperimetric glaucoma, and 111 perimetric glaucoma eyes) was evaluated.Results Using the software-provided classification, for the total population sensitivity did not exceed 73.6% for the optic nerve head parameters, and 62.7% for the other parameters. Specificity was high (94.6-100%) for most RNFLT and GCC parameters, but low (72.0-76.3%) for the optic disc parameters. Positive predictive value varied between 98.1 and 100% for the main RNFLT parameters, 92.6 and 100% for the 16 RNFLT sectors, 92.4 and 99.0% for the GCC parameters, but did not exceed 86.3% for any of the optic disc parameters. Positive likelihood ratio (PLR) was higher than 10 for average, inferior and superior RNFLT (25.5 to infinite), 12 of the 16 RNFLT sectors (12.6 to infinite), and three of the four GCC parameters (40.0 to 48.6). No optic disc parameter had a PLR higher than 3.0.Conclusions RNFLT and GCC parameters of the RTVue-100 Fourier-domain OCT showed moderate sensitive but high specificity, positive predictive value and PLR for detection of glaucoma. The optic disc parameters had lower diagnostic accuracy than the RNFLT and GCC parameters. Eye (2011) 25, 57-65; doi: 10.1038/eye.2010.139; published online 8 October 2010