Age at onset of major depressive disorder predicts reductions in NK cell number and activity
Age at onset of major depressive disorder predicts reductions in NK cell number and activity
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DOI：
10.1016/s0165-0327(01)00395-0
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发表时间：
2002-09-01
影响因子：
6.6
通讯作者：
Johnson, DR
中科院分区：
文献类型：
--
作者：
Frank, MG;Frank, JLW;Johnson, DR
背景资料：重度抑郁症（MDD）与免疫学参数的改变有关，包括自然杀伤细胞活性（NKCA）的降低。然而，免疫功能的改变是否是MDD同质亚组的特征仍然是未知的。本研究探讨了指数发作时的年龄和/或当前MDD发作的持续时间是否可预测NKCA和NK细胞数量的变化。方法：参与者符合DSM-IV MDD标准。通过SCID获得所有受试者（n = 36）MDD发作时的年龄、当前发作的持续时间、人口统计学和合并症。采用汉密尔顿抑郁量表评估MDD的严重程度和症状类型。使用标准铬释放细胞毒性试验测量NKCA，并通过流式细胞术评估NK数量。结果：MDD发病时的年龄显著预测NK细胞数量和NKCA的变化。与以前的研究一致，睡眠障碍和精神发育迟滞分别对NK细胞数量和NKCA的方差具有显著的解释力。局限性：MDD发作时的年龄和当前发作的持续时间的测量是通过自我报告获得的，因此回忆偏倚可能会削弱本研究结果的可靠性。目前的研究设计也排除了关于NK细胞改变与MDD之间时间关联的结论。结论：我们认为，免疫学改变，其特征是抑制NKCA和NK细胞数量伴随着促炎过程，可能构成一个独特的免疫表型早发性抑郁症，并可能是抑郁症的发病机制中的突出因素。(C)2002爱思唯尔科技有限公司。保留所有权利。
Background: Major depressive disorder (MDD) has been associated with altered immunologic parameters including reductions in natural killer cell activity (NKCA). It remains largely unknown, however, whether alterations in immune function characterize homogeneous sub-groups of MDD. The present study addressed the question of whether age at onset of index episode and/or duration of the present episode of MDD predicted alterations in NKCA and NK cell number. Methods: Participants met DSM-IV criteria for MDD. Age at onset of MDD, duration of the present episode, demographics, and comorbidity were obtained by SCID for all subjects (n = 36). Severity and symptom pattern of MDD was assessed by the Hamilton Depression Rating Scale. NKCA was measured using a standard chromium-release cytotoxicity assay and NK number assessed by flow cytometry. Results: Age at onset of MDD significantly predicted variance in NK cell number and NKCA. Consistent with previous studies, sleep disturbance and psychomotor retardation possessed significant explanatory power for variance in NK cell number and NKCA, respectively. Limitations: Measures of age at onset of MDD and duration of the present episode were obtained by self-report and thus recall bias may attenuate the reliability of the present findings. The present study design also precludes conclusions regarding the temporal association between alterations in NK cells and MDD. Conclusions: We propose that immunologic alterations, characterized by a suppression of NKCA and NK cell number concomitant with proinflammatory processes, may constitute an immunologic phenotype unique to early-age-onset depression and may be salient factors in the pathogenesis of depression. (C) 2002 Elsevier Science B.V. All rights reserved.