Application of task-based measures of image quality to optimization and evaluation of three-dimensional reconstruction-based compensation methods in myocardial perfusion SPECT
Application of task-based measures of image quality to optimization and evaluation of three-dimensional reconstruction-based compensation methods in myocardial perfusion SPECT
复制标题
DOI：
10.1109/tmi.2002.804437
复制
发表时间：
2002-09-01
影响因子：
10.6
通讯作者：
Tsui, BMW
中科院分区：
文献类型：
--
作者：
Frey, EC;Gilland, KL;Tsui, BMW
在本文中，我们应用通道化霍特林观测器（CHO）使用缺陷检测任务的优化和评估的三维迭代重建为基础的补偿方法的心肌灌注单光子发射计算机断层扫描（SPECT）。我们使用了一个人口的24个数学的心脏躯干幻影，逼真的活动和衰减分布模型在三类患者：女性和男性与平的隔膜和提高隔膜。投影数据生成，随后重建使用的方法的基础上的有序子集期望最大化（OSEM）算法。评价的方法包括衰减补偿、探测器响应模糊和各种组合的散射。我们应用CHO优化OSEM的迭代次数和三维重建后巴特沃思滤波器的截止频率和阶数。使用最优参数，我们然后比较的补偿方法。这些研究中的比较指数是CHO的受试者工作特征曲线下面积（AUC）。我们发现，与单独的衰减补偿相比，具有检测器响应或散射补偿的衰减补偿在统计学上显著增加了AUC。当应用所有三种补偿时，AUC增加最大。这些结果表明，除了衰减补偿之外，对探测器响应和散射的补偿将改善心肌SPECT图像中的缺陷可检测性。
In this paper, we apply the channelized Hotelling observer (CHO) using a defect detection task to the optimization and evaluation of three-dimensional iterative reconstruction-based compensation methods for myocardial perfusion single-photon emission computed tomography (SPECT). We used a population of 24 mathematical cardiac-torso phantoms that realistically model the activity and attenuation distribution in three classes of patients: females, and males with flat diaphragms and raised diaphragms. Projection data were generated and subsequently reconstructed using methods based on the ordered subsets-expectation maximization (OSEM) algorithm. The methods evaluated included compensation for attenuation, detector response blurring, and scatter in various combinations. We applied the CHO to optimize the number of iterations for OSEM and the cutoff frequency and order of a three-dimensional postreconstruction Butterworth filter. Using the optimal parameters, we then compared the compensation methods. The index of comparison in these studies was the area under the receiver operating characteristics curve (AUC) for the CHO. We found that attenuation compensation with either detector response or scatter compensation gave statistically significant increases in the AUC compared to attenuation compensation alone. The greatest increase in the AUC occurred when all three compensations were applied. These results indicate that compensation for detector response and scatter, in addition to attenuation compensation, will improve defect detectability in myocardial SPECT images.