extra macrochaetae , encoding Drosophila Id, controls apical cell shape in the hindgut epithelium.
extra macrochaetae , encoding Drosophila Id, controls apical cell shape in the hindgut epithelium.
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DOI：
10.17912/micropub.biology.000526
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发表时间：
2022
影响因子：
--
通讯作者：
Matsuno, Kenji
中科院分区：
文献类型：
--
作者：
Ishibashi, Tomoki;Matsuno, Kenji
dna结合（Id）转录因子抑制因子（Inhibitor of DNA-binding转录因子）调节细胞分化和增殖的平衡，参与多种物种的器官形态发生。先前，我们发现编码果蝇唯一Id蛋白的extra macrochaetae （emc）控制后肠上皮细胞形状的手性。为了进一步了解emc在细胞形态调控中的作用，我们分析了emc突变胚后肠上皮的顶端细胞形态。我们发现emc突变体的根尖表面扩大，但细胞分化和增殖没有异常。因此，我们的研究结果表明，Id可以控制细胞形态，而不影响细胞的规格和繁殖。
Inhibitor of DNA-binding (Id) transcription factor regulates the balance of cell differentiation and proliferation and is involved in organ morphogenesis in various species. Previously, we revealed that extra macrochaetae ( emc ), encoding the only Id protein in Drosophila , controls chirality of cell shape in hindgut epithelium. Here, to further understand functions of emc in cell-shape regulations, we analyzed apical cell shape in the hindgut epithelium of emc mutant embryos. We found that emc mutants showed expansion of their apical surface, but no abnormalities in cell differentiation and proliferation. Therefore, our results demonstrate that Id can control cell morphology without affecting specification and propagation of cells.