Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: A dose-response study in humans
Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: A dose-response study in humans
复制标题
DOI：
10.1037/0735-7044.113.3.420
复制
发表时间：
1999-06-01
影响因子：
1.9
通讯作者：
Hauger, RL
中科院分区：
文献类型：
--
作者：
Lupien, SJ;Gillin, CJ;Hauger, RL
在4组10名年轻男性中，测量了不同剂量（40 μ g/kg/hr、300 μ g/kg/hr、600 μ g/kg/hr或安慰剂）氢化可的松对评估工作和陈述性记忆功能的影响。在注射过程中，参与者被分配了一个项目识别工作记忆任务，一个配对关联陈述性记忆任务，以及一个用于控制皮质类固醇对警觉性可能伴随影响的连续表现任务。结果显示，最高剂量氢化可的松对工作记忆功能有显著的急性影响，而对陈述性记忆功能和唤醒警觉性表现无显著影响。这些结果表明，工作记忆比陈述性记忆对皮质类固醇的急性升高更敏感，这可以解释皮质类固醇对信息获取和巩固的有害影响，正如文献报道的那样。
The effects of various doses (40 mu g/kg/hr, 300 mu g/kg/hr, 600 mu g/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate declarative memory task, and a continuous performance task used to control possible concomitant effects of corticosteroids on vigilance. The results revealed significant acute effects of the highest dose of hydrocortisone on working memory function, without any significant effect on declarative memory function or arousal-vigilance performance. These results suggest that working memory is more sensitive than declarative memory to the acute elevations of corticosteroids, which could explain the detrimental effects of corticosteroids on acquisition and consolidation of information, as reported in the literature.