Quantitative T1rho mapping links the cerebellum and lithium use in bipolar disorder.
Quantitative T1rho mapping links the cerebellum and lithium use in bipolar disorder.
复制标题
DOI：
10.1038/mp.2015.10
复制
发表时间：
2015-02-01
影响因子：
11
通讯作者：
Wemmie, J A
中科院分区：
文献类型：
--
作者：
Johnson, C P;Follmer, R L;Wemmie, J A
双相I型障碍是一种常见的使人衰弱的疾病，其原因仍然未知，治疗往往不足。锂和其他疗法减少双相症状的机制也不清楚。在这里，使用一种称为定量T1ρ映射的新型磁共振脑成像技术对处于正常心境的双相I型障碍患者进行成像。T1ρ弛豫时间对代谢因素（例如，pH和葡萄糖）以及组织微观结构特性（例如，细胞密度）敏感，在整个大脑的每个体素处计算。数据表明，双相组与25名无双相障碍的受试者相比存在几个差异，包括小脑T1ρ弛豫时间增加（约翰逊等人）。这些数据进一步表明了锂的一个潜在的有趣作用。在15名患有双相情感障碍的参与者中，6人服用锂（Li+组），9人没有服用锂（Li−组）。在共同的图谱空间中计算Li+和Li−组的平均T1ρ图，并逐体素比较平均组全脑图（Po 0. 05，更正）。该图显示了（从上到下）Li−组与Li+组相比显著升高的体素的冠状、轴向、矢状和三维视图（红色，灰质;黄色，白色物质）。这些图像表明，双相情感障碍患者小脑的T1ρ升高，并可通过锂的使用恢复正常。根据已知的T1ρ敏感性，这些异常可能是代谢性或结构性的。研究更多患有双相情感障碍以及其他疾病的参与者，并进一步表征T1ρ-映射技术可能会导致对这些T1ρ异常的更精确理解，并可能有助于指导寻找新的治疗方法。有关此主题的更多信息，请参阅约翰逊等人的文章第201-206页。
Bipolar I disorder is a common and debilitating disorder for which the causes remain unknown and treatments are often inadequate. Also unclear are the mechanisms by which lithium and other therapies reduce bipolar symptoms. Here, participants with bipolar I disorder in the euthymic state were imaged using a novel magnetic resonance brain imaging technique referred to as quantitative T1ρ mapping. The T1ρ relaxation time, which is sensitive to metabolic factors (for example, pH and glucose) as well as tissue microstructural properties (for example, cellular density), was calculated at each voxel over the whole brain. The data suggest several differences in the bipolar group including increased T1ρ relaxation times in the cerebellum relative to 25 participants without bipolar disorder (Johnson et al.). The data further suggest a potentially interesting effect of lithium. Of the 15 participants with bipolar disorder, six were taking lithium (Li+ group) and nine were not (Li− group). Average T1ρ maps were calculated for the Li+ and Li− groups in a common atlas space, and the average group whole-brain maps were compared voxel-by-voxel (Po0. 05, corrected). The figure shows (from top to bottom) coronal, axial, sagittal and three-dimensional views of the voxels that were significantly elevated in the Li− group compared with the Li+ group (red, gray matter; yellow, white matter). These images suggest T1ρ is elevated in the cerebellum in bipolar disorder and may be normalized with lithium use. On the basis of the known sensitivities of T1ρ, these abnormalities may be metabolic or structural in origin. Studying more participants with bipolar disorder as well as other illnesses, and further characterizing the T1ρ-mapping technique may lead to a more precise understanding of these T1ρ abnormalities, and may help guide the search for new therapies. For more information on this topic, please refer to the article by Johnson et al. on pages 201-206.