Epstein-Barr virus and rheumatoid arthritis
Epstein-Barr virus and rheumatoid arthritis
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DOI：
10.1016/j.autrev.2004.02.002
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发表时间：
2004-07-01
影响因子：
13.6
通讯作者：
Roudier, C
中科院分区：
文献类型：
--
作者：
Balandraud, N;Roudier, J;Roudier, C
类风湿性关节炎（RA）的病因是什么？遗传和环境因素可能有助于其发展。25年来，EB病毒（EBV）一直被怀疑有助于RA的发病机制。RA患者的抗EBV抗体水平高于健康对照组。类风湿性关节炎中EBV特异性抑制性T细胞功能缺陷。HLA-DRB 1 *0404是RA易感等位基因，与EBV gp 110特异性T细胞的低频率相关，EBV gp 110是一种对控制EBV感染至关重要的复制期糖蛋白。RA患者外周血淋巴细胞中的EBV载量（中位数8.84拷贝/500 ng DNA）高于健康对照（中位数0.6拷贝/500 ng DNA）。EBV是一种广泛传播的病毒，被抗体高度识别但从未被消除，是引发慢性免疫复合物疾病的理想候选者。抗EBV抗体反应应被认为是与RA发展最相关的慢性自身抗体反应之一。(C)2004 Elsevier B. V.保留所有权利。
The cause of rheumatoid arthritis (RA) is still unknown. Both genetic and environmental factors may help its development. For 25 years, the Epstein-Barr Virus (EBV) has been suspected to contribute to RA pathogenesis. RA patients have higher levels of anti-EBV antibodies than healthy controls. EBV-specific suppressor T cell function is defective in RA. HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection. Patients with RA have higher EBV load in peripheral blood lymphocytes (median 8.84 copies per 500 ng DNA) than healthy controls (median 0.6 copies/500 ng DNA). EBV, a widespread virus, highly recognized by antibodies but never eliminated, is an ideal candidate to trigger chronic immune complex disease. Anti-EBV antibody responses should be considered as one of the chronic autoantibody responses that are most relevant to the development of RA. (C) 2004 Elsevier B.V. All rights reserved.