Investigation and validation of intersite fMRI studies using the same imaging hardware.
Investigation and validation of intersite fMRI studies using the same imaging hardware.
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DOI：
10.1002/jmri.21419
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发表时间：
2008-07
影响因子：
4.4
通讯作者：
Park, Denise C.
中科院分区：
文献类型：
--
作者：
Sutton, Bradley P.;Goh, Joshua;Hebrank, Andrew;Welsh, Robert C.;Chee, Michael W. L.;Park, Denise C.
在配备相同成像硬件和软件的两个实验室中，提供功能磁共振(FMRI)信号重复性的现场比较。许多研究着眼于受试者的可靠性，最近的努力已经开始校准不同地点、磁场强度和软件的反应。通过比较相同的成像硬件和软件，我们为未来的多点比较提供了一个基准。我们根据幻影扫描的噪声和稳定性特性以及在两个地点对相同的四个受试者重复运行受阻的运动和视觉任务的对比估计来评估系统的兼容性。方差分析和ROI分析证实，在我们的大型fMRI数据集中，SITE在解释差异方面没有发挥重要作用。效应大小分析表明，受试者之间的差异解释的差异几乎是现场效应的十倍。我们表明，来自认知实验的对比度估计的定量比较可以可靠地跨两个地点进行比较。这使我们能够建立一个有效的平台，当群体效应可能与地点混淆时，使用功能磁共振成像来比较两个地点之间的小组差异，例如在国家之间的神经文化差异研究或多中心临床试验中。
To provide a between site comparison of functional MRI (fMRI) signal reproducibility in two laboratories equipped with identical imaging hardware and software. Many studies have looked at within subject reliability and more recent efforts have begun to calibrate responses across sites, magnetic field strengths, and software. By comparing identical imaging hardware and software, we provide a benchmark for future multi-site comparisons. We evaluated system compatibility based on noise and stability properties of phantom scans and contrast estimates from repeated runs of a blocked motor and visual task on the same four subjects at both sites. ANOVA and ROI analysis confirmed that site did not play a significant role in explaining variance in our large fMRI data set. Effect size analysis shows that between-subject differences account for nearly ten times more variance than site effects. We show that quantitative comparisons of contrast estimates derived from cognitive experiments can reliably be compared across two sites. This allows us to establish an effective platform for comparing group differences between two sites using fMRI when group effects are potentially confounded with site, as in the study of neurocultural differences between countries or multi-center clinical trials.
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