Patterns of Acute Rhesus Cytomegalovirus (RhCMV) Infection Predict Long-Term RhCMV Infection
Patterns of Acute Rhesus Cytomegalovirus (RhCMV) Infection Predict Long-Term RhCMV Infection
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DOI：
10.1128/jvi.00607-12
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发表时间：
2012-06-01
影响因子：
5.4
通讯作者：
Barry, Peter A.
中科院分区：
文献类型：
--
作者：
Assaf, Basel T.;Mansfield, Keith G.;Barry, Peter A.
我们曾报道感染猕猴的恒河猴巨细胞病毒（RhCMV）的长期排泄与UL/B'编码含量有关。目前已对先前研究中接种部位的急性活检标本进行了分析，以确定是否存在长期RhCMV感染的急性表型预测因子。仅在显示急性内皮嗜性和嗜酸性炎症的动物中检测到RhCMV排泄。结果表明，针对这些早期病毒决定因素的疫苗接种将显着阻碍长期RhCMV感染。
We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.