Phenelzine for chronic depression: a study of continuation treatment.
Phenelzine for chronic depression: a study of continuation treatment.
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苯乙肼治疗慢性抑郁症：一项持续治疗的研究。
DOI：
10.1017/s104161028900013x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
F. Quitkin
中科院分区：
文献类型：
--
作者：
W. Harrison;J. Rabkin;J. Stewart;P. McGrath;E. Tricamo;F. Quitkin
几项对照研究已经证实了三环类抗抑郁药持续治疗的有效性，但对单胺氧化酶抑制剂的持续治疗知之甚少。此外，慢性抑郁症患者持续抗抑郁治疗的有效性尚未得到评估。这项初步研究报告了一项双盲持续试验的初步结果，苯乙肼或安慰剂后，最初的抗抑郁药反应苯乙肼在12例符合DSM-III标准的心境恶劣障碍。所有7名随机分配至安慰剂组的患者均复发，而5名继续接受苯乙肼治疗的患者中仅1名复发。这些结果表明，继续治疗苯乙肼可能是有用的，在维持急性治疗后的临床反应。
Several controlled studies have demonstrated the efficacy of continuation therapy with tricyclic antidepressants, but little is known about continuation therapy with the monoamine oxidase inhibitors. Moreover, the usefulness of continuation antidepressant therapy in patients with chronic depressive disorders has not been evaluated. This pilot study reports initial results of a double-blind continuation trial of phenelzine or placebo following an initial antidepressant response to phenelzine in 12 patients who met DSM-III criteria for dysthymic disorder. All 7 patients randomized to placebo relapsed, whereas only 1 of the 5 patients who continued to receive phenelzine relapsed. These results suggest that continuation therapy with phenelzine may be useful in maintaining clinical response after acute treatment.