Impact of Skeletal Muscle Mass on Metabolic Health
Impact of Skeletal Muscle Mass on Metabolic Health
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DOI：
10.3803/enm.2020.35.1.1
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发表时间：
2020-03-01
影响因子：
3.4
通讯作者：
Kim, Jae Hyeon
中科院分区：
文献类型：
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作者：
Kim, Gyuri;Kim, Jae Hyeon
骨骼肌被认为是一个内分泌和旁分泌器官。肌肉来源的分泌蛋白，被称为肌因子，介导骨骼肌质量和其他器官（如肝脏、脂肪组织、胰腺、骨骼和心血管系统）之间的相互作用。随着个人年龄的增长，体力活动水平的降低和肌肉减少症（骨骼肌质量和力量的丧失）与身体虚弱和残疾有关。最近，一些研究表明，骨骼肌质量的减少可能导致代谢性疾病。因此，在本文中，我们关注骨骼肌质量与代谢疾病，包括代谢综合征和非酒精性脂肪性肝病之间的关系。
Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diceaces, including metabolic syndrome and non-alcoholic fatty liver disease.