Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity
Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity
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DOI：
10.1016/j.cell.2016.06.027
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发表时间：
2016-08-11
期刊：
影响因子：
64.5
通讯作者：
Noel, Joseph P.
中科院分区：
文献类型：
--
作者：
Weng, Jing-Ke;Ye, Mingli;Noel, Joseph P.
传统上，激素通过激活专门的受体来引发特定的细胞反应。然而，许多这些激素分子的生物合成和转换也产生化学相关的代谢物。这些分子也可能具有激素活性；因此，一个或多个可能有助于宿主生物信号结果的适应性可塑性。在这里，我们表明植物激素脱落酸（ABA）的分解产物，即相酸（PA），可能作为一种信号分子出现在种子植物中，微调植物生理、环境适应和发育。这一特性得益于调节PA浓度的PA还原酶的出现和选择，以及ABA受体家族感知和响应PA的功能多样化。我们的研究结果表明，PA通过激活ABA受体的一个子集在种子植物中发挥激素的作用。该研究表明，激素代谢和信号网络的共同进化可以扩大生物体的弹性。
Classically, hormones elicit specific cellular responses by activating dedicated receptors. Nevertheless, the biosynthesis and turnover of many of these hormone molecules also produce chemically related metabolites. These molecules may also possess hormonal activities; therefore, one or more may contribute to the adaptive plasticity of signaling outcomes in host organisms. Here, we show that a catabolite of the plant hormone abscisic acid (ABA), namely phaseic acid (PA), likely emerged in seed plants as a signaling molecule that fine-tunes plant physiology, environmental adaptation, and development. This trait was facilitated by both the emergence- selection of a PA reductase that modulates PA concentrations and by the functional diversification of the ABA receptor family to perceive and respond to PA. Our results suggest that PA serves as a hormone in seed plants through activation of a subset of ABA receptors. This study demonstrates that the co-evolution of hormone metabolism and signaling networks can expand organismal resilience.