Function of Nod-like receptors in microbial recognition and host defense.
Function of Nod-like receptors in microbial recognition and host defense.
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DOI：
10.1111/j.1600-065x.2008.00734.x
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发表时间：
2009-01
影响因子：
8.7
通讯作者：
Nuñez G
中科院分区：
文献类型：
--
作者：
Franchi L;Warner N;Viani K;Nuñez G
核苷酸寡聚化结构域（NOD）样受体（NLRs）是一类特殊的细胞内蛋白，在宿主先天免疫反应的调控中起关键作用。NLRs作为支架蛋白，组装信号平台，触发核因子-κB和丝裂原激活的蛋白激酶信号通路，控制炎症性半胱天冬酶的激活。重要的是，NLR家族几个成员的突变与多种炎症性疾病有关，这些分子在宿主-病原体相互作用和炎症反应中发挥重要作用。在这篇综述中，我们重点关注Nod1和Nod2在宿主防御中的作用，并特别讨论了Nlrc4、Nlpr1和Nlrp3炎症小体在caspase-1激活和随后的促炎细胞因子（如白细胞介素-1β）释放中的作用。
Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1β.