Gram-Scale Total Synthesis of Sarpagine Alkaloids and Non-Natural Derivatives
Gram-Scale Total Synthesis of Sarpagine Alkaloids and Non-Natural Derivatives
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DOI：
10.1002/chem.201805644
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发表时间：
2019-02-21
影响因子：
4.3
通讯作者：
Gaich, Tanja
中科院分区：
文献类型：
--
作者：
Rebmann, Heiko;Gerlinger, Christa K. G.;Gaich, Tanja
这项工作描述了通过改进的合成序列全合成沙巴碱生物碱家族的三个成员和十个非天然同系物，该合成序列专为适合结构-活性关系(SAR)研究的材料的克级生产而设计。此外，手稿详细说明了如何使用合成路线来获得与生物遗传完全无关的Stemona生物碱Parvineoystonine(34)，为有效的合成设计提供了一个展示窗口。
This work describes the total synthesis of three members of the sarpagine alkaloid family and ten non-natural congeners through an improved synthetic sequence, which was designed for gram-scale production of materials suited for structure-activity relationship (SAR) studies. Furthermore, the manuscript details how the synthetic route was used to access the biogenetically completely unrelated Stemona alkaloid parvineostemonine (34), providing a showcase for efficient synthetic design.