Manipulation of object choice by electrical microstimulation in macaque frontal eye fields
Manipulation of object choice by electrical microstimulation in macaque frontal eye fields
复制标题
通过电微刺激控制猕猴额眼区域的物体选择
DOI：
10.1093/cercor/bht009
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Matsushima A and Tanaka M
中科院分区：
文献类型：
--
作者：
Matsushima;A. & Tanaka;M.;Matsushima A and Tanaka M
对于每一次扫视，我们选择一个对象来引导凝视，并指定眼球运动的方向和幅度。虽然当视觉刺激保持静止时，这两个过程不可避免地相互依赖，但一些证据表明，在视觉对象选择基础上的额叶视野（FEF）中的神经元信号与在扫视选择基础上的神经元信号不同。在本研究中，我们使用隐蔽的对象跟踪范式，在猴子对先前选择的目标进行扫视之前，4个相同的物体随机移动3秒，从而在空间和时间上公开分离这两个过程。为了评估FEF在两个选择过程中的因果作用，我们在运动期间的不同时间对FEF施加电微刺激。当在运动开始时进行刺激时，动物倾向于根据刺激部位选择最初出现在特定位置的物体。相比之下，在运动端施加同样的刺激，却不能改变扫视的终点。这些结果表明，操纵FEF活动可以改变视觉对象的选择而不影响扫视目标，表明存在单独调节视觉选择的神经元。
For each saccade, we select an object to direct gaze and to specify the direction and amplitude of eye movement. Although these 2 processes are inevitably interdependent when visual stimuli are held stationary, several lines of evidence suggest that the neuronal signals in the frontal eye fields (FEF) that underlie the selection of visual objects are distinct from those underlying the selection of saccades. In the present study, we overtly dissociated these 2 processes spatially and temporally using the covert object-tracking paradigm, in which 4 identical objects moved randomly for 3 s before monkeys made a saccade to a previously selected target. To assess the causal role of the FEF in the 2 selection processes, we applied electrical microstimulation to the FEF at various times during the motion period. When stimulation was delivered at the motion onset, animals tended to choose an object that was initially presented at a particular location depending on the stimulation site. In contrast, the same stimulation delivered at the motion end failed to alter saccade end points. These results indicate that manipulation of FEF activity can change the selection of a visual object without affecting saccade goals, suggesting the existence of neurons solely regulating visual selection.