The Role of p110d in the Development and Activation of B Lymphocytes.
The Role of p110d in the Development and Activation of B Lymphocytes.
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p110d 在 B 淋巴细胞发育和激活中的作用。
DOI：
10.1007/978-3-319-15774-0_9
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发表时间：
2015
影响因子：
--
通讯作者：
Newman R
中科院分区：
文献类型：
--
作者：
Newman R
磷脂酰肌醇-3-激酶(PI3K)通路在细胞增殖、分化、发育、迁移和生长等多种不同的细胞过程中起着重要的信号转导作用。在免疫系统中，PI3K通过控制白细胞的激活和募集来调节炎症。条件性基因敲除小鼠的产生使得对B和T淋巴细胞中的PI3K亚型的研究成为可能，并证明了完整的信号在它们的发育和功能中的重要性。PI3K信号在淋巴细胞中必须受到严格的调控，因为过量的PI3K可能导致自身免疫、免疫缺陷或癌症，而信号减弱可能导致发育缺陷和免疫缺陷。最近在理解PI3K信号方面的进展加速了异构体特异性PI3K抑制剂的应用，目前正在进行临床试验。本文就PI3K的δ催化亚单位及其下游效应在B淋巴细胞发育和激活中的作用作一综述。
The phosphatidylinositol-3-kinase (PI3K) pathway has an essential role in signal transduction, where it is required for a number of different cellular processes including proliferation, differentiation, development, migration and growth. In the immune system, PI3K regulates inflammation by controlling the activation and recruitment of leukocytes. The generation of conditional knockout mice has allowed the study of PI3K isoforms specifically in B and T lymphocytes, and demonstrates the importance of intact signalling in their development and function. PI3K signalling must be tightly regulated in lymphocytes as excessive PI3K can lead to autoimmunity, immunodeficiency or cancer, whilst diminished signalling can result in developmental defects and immunodeficiency. Recent advances in the understanding of PI3K signalling have hastened the application of isoform-specific PI3K inhibitors, which are currently undergoing clinical trials. This review will focus on the p110δ catalytic subunit of the class 1A family of PI3K, and its role in the development and activation of B lymphocytes through various downstream effectors.