Acute exercise and oxidative stress: a 30 year history.
Acute exercise and oxidative stress: a 30 year history.
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DOI：
10.1186/1476-5918-8-1
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发表时间：
2009-01-13
期刊：
影响因子：
--
通讯作者：
Bloomer, Richard J
中科院分区：
文献类型：
--
作者：
Fisher-Wellman, Kelsey;Bloomer, Richard J
运动诱导的氧化应激的主题近年来受到了相当大的关注，自1978年Dillard及其同事的早期工作以来，发表了近300项原始研究。单次有氧和无氧运动会导致急性氧化应激状态。这是由各种组织中氧化分子的存在增加所指示的。运动模式、强度和持续时间，以及受试者群体，都可能影响氧化程度。此外，使用抗氧化剂补充剂可能会影响研究结果。虽然一轮运动往往会导致急性氧化应激，根据兴奋效应的原则，这种增加似乎是必要的，允许内源性抗氧化防御上调。本文综述了运动引起的氧化应激的研究进展。这应该为读者提供一个有据可查的帐户内所做的研究这一领域的科学在过去30年。
The topic of exercise-induced oxidative stress has received considerable attention in recent years, with close to 300 original investigations published since the early work of Dillard and colleagues in 1978. Single bouts of aerobic and anaerobic exercise can induce an acute state of oxidative stress. This is indicated by an increased presence of oxidized molecules in a variety of tissues. Exercise mode, intensity, and duration, as well as the subject population tested, all can impact the extent of oxidation. Moreover, the use of antioxidant supplements can impact the findings. Although a single bout of exercise often leads to an acute oxidative stress, in accordance with the principle of hormesis, such an increase appears necessary to allow for an up-regulation in endogenous antioxidant defenses. This review presents a comprehensive summary of original investigations focused on exercise-induced oxidative stress. This should provide the reader with a well-documented account of the research done within this area of science over the past 30 years.