Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer
Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer
复制标题
Slit2在甲状腺乳头状癌中的表达、临床意义及机制
DOI：
10.3892/ijo.2016.3412
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发表时间：
2016-05-01
影响因子：
5.2
通讯作者：
Ji, Qing-Hai
中科院分区：
文献类型：
--
作者：
Shi, Rong-Liang;Qu, Ning;Ji, Qing-Hai
甲状腺癌是一种常见的内分泌恶性肿瘤。在过去的十年中，在了解甲状腺癌分子发病机制方面取得了令人兴奋的进展。几个主要的信号通路和相关的分子紊乱已被阐明，这是新的甲状腺癌的诊断和预后的分子标志物。基于甲状腺癌的分子生物学，一系列的治疗靶点被开发出来，这提供了前所未有的机遇。因此，患者亚组的组织学表征和患者的正确分子表征被认为是这些患者未来临床管理的关键方面。在本研究中，我们将Slit2确定为甲状腺癌发生和复发的预后标志物。Slit 2通过调节HIF 1 α和HIF 1 α转录活性来调节甲状腺癌细胞中的瓦尔堡效应。总之，我们目前的数据揭示了Slit2作为甲状腺癌的一种新的预测标志物。机制研究表明，Slit 2调节瓦尔堡效应。需要对Slit2在甲状腺癌中的功能进行进一步研究，以提供对甲状腺癌发生和复发潜力的潜在机制的新见解。
Thyroid cancer is a common endocrine malignancy. The last decade has seen exciting progress in understanding thyroid cancer molecular pathogenesis. Several major signaling pathways and related molecular derangements have been elucidated, which represent novel diagnostic and prognostic molecular markers for thyroid cancer. Based on the molecular biology of thyroid cancer, a series of therapeutic targets have been developed, which provide unprecedented opportunities. Thus, histological characterization of subgroups of patients and the correct molecular characterization of patients are thought to be key aspects for future clinical management of these patients. In the present study, we identified Slit2 as a prognostic marker for thyroid cancer oncogenesis and recurrence. Mechanistically, Slit2 regulated Warburg effect in thyroid cancer cells through regulation of HIF1α and HIF1α transcriptional activity. Taken together, our present data uncovered Slit2 as a novel predictive marker for thyroid cancer. The mechanism study indicated that Slit2 regulated the Warburg effect. Additional study on the function of Slit2 in thyroid cancer is required to provide new insights into the potential mechanisms of oncogenesis and recurrence potential of thyroid cancer.