Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study.
Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study.
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DOI：
10.2196/31885
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发表时间：
2022-02-10
影响因子：
1.7
通讯作者：
Butterworth AS
中科院分区：
文献类型：
--
作者：
Chowdhury R;Noh MFM;Ismail SR;van Daalen KR;Kamaruddin PSNM;Zulkiply SH;Azizul NH;Khalid NM;Ali A;Idris IM;Mei YS;Abdullah SR;Faridus N;Yusof NAM;Yusoff NNFM;Jamal R;Rahim AAA;Ghapar AKA;Radhakrishnan AK;Fong AYY;Ismail O;Krishinan S;Lee CY;Bang LH;Mageswaren E;Mahendran K;Amin NHM;Muthusamy G;Jin AOH;Ramli AW;Ross NT;Ruhani AI;Yahya M;Yusoff Y;Abidin SKZ;Amado L;Bolton T;Weston S;Crawte J;Ovenden N;Michielsen A;Monower MM;Mahiyuddin WRW;Wood A;Di Angelantonio E;Sulaiman NS;Danesh J;Butterworth AS
尽管马来西亚早发性心肌梗死(MI)的负担很高，但关于这一多种族人口中MI决定因素的直接证据仍然很少。马来西亚急性血管事件风险研究(MAVERIK)是一项回顾性病例对照研究，旨在调查马来西亚急性心肌梗死的基因组、脂质相关和其他决定因素。在本文中，我们报告了研究方案和初步结果。截至2019年6月，我们从马来西亚的17家医院招募了大约2500名首次心肌梗死患者和2500名无心血管疾病的对照患者，他们在年龄、性别和种族方面进行了频率匹配。对于每个参与者，都收集并存储了血清和全血。临床、人口统计学和行为信息已经通过200个项目的问卷获得。吸烟、糖尿病、高血压病史、内脏肥胖症标志物、社会经济地位较低的指标以及冠心病家族史在病例组中比对照组更常见。对传统危险因素进行调整(年龄和性别)的Logistic回归模型显示，当前吸烟(OR)4.11，95%CI 3.56-4.75；P<；.001)，既往吸烟(OR 1.34，95%CI 1.12-1.60；P=.001)，高血压病史(OR 2.13，95%CI 1.86-2.44；P<；.001)，糖尿病病史(OR 2.72，95%CI 2.34-3.17；P<；在年龄和性别调整的模型中，冠心病家族史(OR 1.28，95%CI 1.07-1.55；P=.009)和肥胖(BMI和GT；30 kg/m2；OR 1.19，95%CI 1.05-1.34；P=.009)与MI有关。MAVERIK研究可以作为一个有用的平台，在研究不足的东南亚人群中调查心肌梗死的遗传和其他风险因素。它应该有助于加速发现致病途径，并为优化公共卫生行动的区域适当战略提供信息。RR1-10.2196/31885
Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P<.001), previous smoking (OR 1.34, 95% CI 1.12-1.60; P=.001), a history of high blood pressure (OR 2.13, 95% CI 1.86-2.44; P<.001), a history of diabetes mellitus (OR 2.72, 95% CI 2.34-3.17; P<.001), a family history of coronary heart disease (OR 1.28, 95% CI 1.07-1.55; P=.009), and obesity (BMI >30 kg/m2; OR 1.19, 95% CI 1.05-1.34; P=.009) were associated with MI in age- and sex-adjusted models. The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an understudied Southeast Asian population. It should help to hasten the discovery of disease-causing pathways and inform regionally appropriate strategies that optimize public health action. RR1-10.2196/31885
影响因子：
4.5
作者：
Clarke R;Xu P;Bennett D;Lewington S;Zondervan K;Parish S;Palmer A;Clark S;Cardon L;Peto R;Lathrop M;Collins R;International Study of Infarct Survival (ISIS) Collaborators
通讯作者：
International Study of Infarct Survival (ISIS) Collaborators