Sequence of a cDNA clone encoding chicken ribosomal protein S17.
Sequence of a cDNA clone encoding chicken ribosomal protein S17.
复制标题
编码鸡核糖体蛋白 S17 的 cDNA 克隆序列。
DOI：
10.1093/nar/16.10.4723
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发表时间：
1988
影响因子：
14.9
通讯作者：
E. Strehler
中科院分区：
文献类型：
--
作者：
B. Trüeb;T. Schreier;K. Winterhalter;E. Strehler
真核生物核糖体蛋白质序列在进化研究中具有特殊的意义，因为不同生物体的核糖体在亚基结构和功能上具有显著的相似性。我们在这里报告的序列克隆的cDNA编码鸡核糖体蛋白SI 7。该cDNA含有387个核苷酸的编码序列，对应于氨基酸残基7-135，43个核苷酸的3'非翻译区和一个短的poly（A）尾。我们试图分离5'非翻译区的cDNA，但至今没有成功。预测的氨基酸序列与人和仓鼠的氨基酸序列相同，除了羧基末端的两个残基（Ala-Leu，与Pro-Val和Ala-Val相比）（1）。在核苷酸水平上，鸡的序列与人、仓鼠和大鼠的序列有82%的同源性（1，2）。在下图中，人核苷酸序列（1）包括在与鸡序列不同的任何地方。
Sequences of eukaryotic ribosomal proteins are of particular interest for evolutionary studies because ribosomes from different organisms show remarkable similarities in subunit structure and function. We report here the sequence of a cloned cDNA that encodes chicken ribosomal protein SI7. This cDNA contains 387 nucleotides of the coding sequence corresponding to amino acid residues 7-135, 43 nucleotides of the 3' untranslated region and a short poly(A) tail. Our attempts to isolate a cDNA for the 5' untranslated region have not been successful so far. The predicted amino acid sequence is identical to that of man and hamster except for the two residues at the carboxyl terminus (Ala-Leu as compared to Pro-Val and Ala-Val) (1). On the nucleotide level, the chicken sequence is 82% homologous to the sequences of man, hamster and rat (1, 2). In the figure below the human nucleotide sequence (1) is included wherever it differs from the chicken sequence.