One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia.
One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia.
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DOI：
10.3389/fimmu.2021.618710
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发表时间：
2021
影响因子：
7.3
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Wang Z;Chen J;Wang M;Zhang L;Yu L
T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy.
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