Transcriptional control of chondrocyte fate and differentiation
Transcriptional control of chondrocyte fate and differentiation
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DOI：
10.1002/bdrc.20048
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发表时间：
2005-09-01
影响因子：
2.1
通讯作者：
Smits, Patrick
中科院分区：
文献类型：
--
作者：
Lefebvre, Veronique;Smits, Patrick
软骨形成是脊椎动物的一个重要过程。它导致软骨生长板的形成，软骨生长板驱动身体生长并在软骨内骨化中起主要作用。它还导致永久性软骨组织的形成，为终生的关节、呼吸道和听觉道提供主要的结构支撑。软骨形成缺陷导致软骨软骨发育不良和软骨发育不良。这些骨骼畸形疾病在人类出生缺陷中占很大比例，并且可以极大地影响一个人的预期和生活质量。当多能间充质细胞分化为软骨细胞谱系并通过一系列分化步骤构建时，就会发生软骨形成。最终重塑软骨。本综述总结并讨论了我们目前对软骨细胞分化途径（从间充质细胞到生长板和关节软骨细胞）的认识和缺乏认识，主要关注组织模式和细胞分化转录因子（例如但不限于Pax1和Pax9、Nkx3.1和Nkx3.2、Sox9、Sox5和Sox6、Runx2和Runx3以及c-Maf）如何控制软骨细胞分化途径。
Chondrogenesis is an essential process in vertebrates. It leads to the formation of cartilage growth plates, which drive body growth and have primary roles in endochondral ossification. It also leads to the formation of permanent cartilaginous tissues that provide major structural support in the articular joints and respiratory and auditory tracts throughout life, Defects in chondrogenesis cause chondrodysostoses and chondrodysplasias. These skeletal malformation diseases account for a significant proportion of birth defects in humans and can dramatically affect a person's expectancy and quality of life. Chondrogenesis occurs when pluripotent mesenchymal cells commit to the chondrocyte lineage, and through a series of differentiation steps build and. eventually remodel cartilage. This review summarizes and discusses our current knowledge and lack of knowledge about the chondrocyte differentiation pathway, from mesenchymal cells to growth plate and articular chondrocytes, with a main focus on how it is controlled by tissue patterning and cell differentiation transcription factors, such as, but not limited to, Pax1 and Pax9, Nkx3.1 and Nkx3.2, Sox9, Sox5 and Sox6, Runx2 and Runx3, and c-Maf.