Malaria prophylaxis in post renal transplant recipients in the tropics: is it necessary?
Malaria prophylaxis in post renal transplant recipients in the tropics: is it necessary?
复制标题
热带地区肾移植受者的疟疾预防：有必要吗？
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
A. Gbaji
中科院分区：
文献类型：
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作者：
Anteyi Ea;Liman Hm;A. Gbaji
目标
在疟疾流行区，通常不为大多数肾移植后接受者提供常规疟疾预防。因此，很少有信息是已知的这种疾病的发病率和严重程度之间的移植后受体在我们的环境。因此，在尼日利亚进行了一项前瞻性、非随机、开放标签的临床试验，以确定肾移植受者中疟疾的发病率和预防疟疾的有益效果。
科目
所有7名连续接受肾移植并在不超过4周后返回单位的患者均接受了观察和随访。这包括最初4周的无预防期和另外4周的每日200 mg盐酸氯胍预防期。每周检查一次吉姆萨染色薄血片和厚血片，并进行肝功能检查、全血细胞计数、尿素、肌酐、电解质和尿液分析等常规检查。
结果
在最初的无预防阶段，7名患者中只有3名（42.8%）疟疾寄生虫涂片阳性。在预防阶段未检测到疟原虫。两个阶段之间的其他检查结果（包括肾功能）无显著差异。
结论
这项研究表明，在疟疾流行区的肾移植受者中，短期常规疟疾预防是有益的。
OBJECTIVES
Malaria prophylaxis is usually not provided routinely for most post renal transplant recipients in malaria endemic zones. Therefore, very little information is known about the incidence and severity of this disease among the post-transplant recipients in our environment. Hence a prospective, non-randomized open label clinical trial to determine the incidence of malaria and the beneficial effect of malaria prophylaxis among renal transplant recipients in Nigeria was carried out.
SUBJECTS
All seven consecutive patients who had renal transplants and returned to the unit not more than four weeks later were seen and followed up. This consisted of an initial four week period of no prophylaxis and another four weeks of prophylaxis with proguanil hydrochloride 200 mg daily. Weekly thin and thick blood films by Giemsa stain were examined and other routine investigations of liver function tests, full blood count, urea, creatinine, electrolytes and urinalysis were done.
RESULTS
Only three out of the seven patients (42.8%) had positive smears for malaria parasites in the initial no prophylaxis phase. No malaria parasites were detected at the prophylactic phase. There was no significant difference in the results of other investigations including the renal function between the two phases.
CONCLUSION
This study has shown the benefit of short term routine malaria prophylaxis among renal transplant recipients in malaria endemic zones.