Genetics of Type 2 Diabetes in East Asian Populations
Genetics of Type 2 Diabetes in East Asian Populations
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DOI：
10.1007/s11892-012-0326-z
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发表时间：
2012-12-01
影响因子：
4.2
通讯作者：
Nho, Chu Won
中科院分区：
文献类型：
--
作者：
Cho, Yoon Shin;Lee, Jong-Young;Nho, Chu Won
由于2型糖尿病（T2D）是高度家族性的，在过去的十年里，人们一直在努力揭示T2D的遗传基础。与欧洲人相比，东亚人的体重指数相对较低，因此t2dm的患病率正在迅速上升。迄今为止，从东亚人的大规模全基因组关联研究和荟萃分析中已经确定了至少15个令人信服的T2D位点。欧洲人的研究表明，其中许多可能与胰腺细胞功能有关。许多T2D基因座在不同的族群中被复制。然而，这些风险等位基因的频率和效应大小在种族间存在实质性差异。尽管积累了有关T2D的遗传信息，但我们解释东亚地区快速上升的患病率和低表型疾病的能力仍然有限，这表明未来需要使用多种研究策略进行更广泛的工作。
Because type 2 diabetes (T2D) is highly familial, there has been a concentrated effort to uncover the genetic basis of T2D worldwide over the last decade. In East Asians, T2D is experiencing a rapidly rising prevalence that is characterized by a relatively lower body mass index, as compared with that in Europeans. To date, at least 15 convincing T2D loci have been identified from large-scale genome-wide association studies and meta-analyses in East Asians. Many of these are likely responsible for pancreatic beta cell function, as indicated in studies from Europeans. Many T2D loci have been replicated across the ethnic groups. There are, however, substantial interethnic differences in frequency and effect size of these risk alleles. Despite accumulating genetic information on T2D, there are still limitations in our ability to explain the rapidly rising prevalence and lean phenotype of disease observed in East Asians, suggesting that more extensive work using diverse research strategies is needed in the future.