Antioxidants and resistance against oxidation of porcine LDL subfractions.
Antioxidants and resistance against oxidation of porcine LDL subfractions.
复制标题
猪低密度脂蛋白亚组分的抗氧化剂和抗氧化性。
DOI：
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发表时间：
1990
影响因子：
6.5
通讯作者：
H. Esterbauer
中科院分区：
文献类型：
--
作者：
G. Knipping;M. Rotheneder;G. Striegl;H. Esterbauer
本研究的目的是确定天然猪LDL 1和LDL 2的抗氧化剂水平，脂肪酸和过氧化产物的含量，以及抗氧化性。两种天然低密度脂蛋白（LDL）亚组分的脂肪酸分布无显著差异，与人LDL相似。猪LDL中α-和γ-生育酚的总量显著低于人LDL，β-胡萝卜素、番茄红素和视黄酯完全不存在。硫代巴比妥酸反应物质（TBARS）和脂质过氧化物在新鲜分离的猪LDL亚组分的水平低于或仅略高于检测限。通过添加Cu 2+作为助氧化剂，研究了两种LDL亚组分对氧化的敏感性。结果表明，猪低密度脂蛋白亚组分更容易氧化的滞后期的持续时间之前的快速脂质过氧化反应的开始测量。从维生素E的低含量，人们可以预期甚至更短的滞后期。因此，猪的低密度脂蛋白可能含有额外的，但尚未确定的抗氧化剂。
The objective of this study was to determine the level of antioxidants, the content of fatty acids and peroxidation products, and the resistance against oxidation of native porcine LDL1 and LDL2. There were no significant differences in the fatty acid distribution of both native low density lipoprotein (LDL) subfractions, which was similar to that of human LDL. The total amount of alpha- and gamma-tocopherol of pig LDL was significantly lower than in human LDL, and beta-carotene, lycopene, and retinyl esters were totally absent. Levels of thiobarbituric acid-reacting substances (TBARS) and lipid peroxides in freshly isolated pig LDL subfractions were below or only slightly above the detection limit. The susceptibility to oxidation of both LDL subfractions was investigated by addition of Cu2+ as prooxidant. The results show that pig LDL subfractions are much more susceptible to oxidation as measured by the duration of the lag phase preceding the onset of rapid lipid peroxidation. From the low content of vitamin E one would expect even much shorter lag phases. The possibility therefore exists that pig LDL contains additional, and as yet unidentified, antioxidants.
DOI：
10.1073/pnas.81.12.3883
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
STEINBRECHER, UP;PARTHASARATHY, S;STEINBERG, D
通讯作者：
STEINBERG, D
赖氨酸在介导修饰低密度脂蛋白与人单核巨噬细胞清道夫受体相互作用中的作用。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Haberland,ME;Olch,CL;Folgelman,AM
通讯作者：
Folgelman,AM