Metabolic changes in pregnancy
Metabolic changes in pregnancy
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DOI：
10.1097/grf.0b013e31815a5494
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发表时间：
2007-12-01
影响因子：
1.5
通讯作者：
Catalano, Patrick M.
中科院分区：
文献类型：
--
作者：
Lain, Kristine Y.;Catalano, Patrick M.
母体代谢在怀孕期间发生重大变化。妊娠早期可以被视为母体的合成代谢状态，母体脂肪储存增加，胰岛素敏感性略有增加。因此，营养物质在妊娠早期储存，以满足妊娠后期和哺乳期胎儿-胎盘和母体的需求。相反，晚期妊娠更好地表征为胰岛素敏感性降低（胰岛素抵抗增加）的分解代谢状态。胰岛素抵抗的增加导致母体葡萄糖和游离脂肪酸浓度增加，从而为胎儿生长提供更大的底物可用性。
Maternal metabolism changes substantially during pregnancy. Early gestation can be viewed as an anabolic state in the mother with an increase in maternal fat stores and small increases in insulin sensitivity. Hence, nutrients are stored in early pregnancy to meet the feto-placental and maternal demands of late gestation and lactation. In contrast, late pregnancy is better characterized as a catabolic state with decreased insulin sensitivity (increased insulin resistance). An increase in insulin resistance results in increases in maternal glucose and free fatty acid concentrations, allowing for greater substrate availability for fetal growth.