Association Between Hypoxemia and Mortality in Patients With COVID-19
Association Between Hypoxemia and Mortality in Patients With COVID-19
复制标题
DOI：
10.1016/j.mayocp.2020.04.006
复制
发表时间：
2020-06-01
影响因子：
8.9
通讯作者：
Somers, Virend K.
中科院分区：
文献类型：
--
作者：
Xie, Jiang;Covassin, Naima;Somers, Virend K.
目的：确定与2019冠状病毒病（COVID-19）相关肺炎患者院内死亡相关的标志物。患者和方法：对2020年1月28日至2020年2月28日期间在中国武汉协和医院住院并随访至2020年3月13日的140名需要吸氧的中危型COVID-19相关肺炎患者进行了回顾性队列研究。在生存分析中，氧饱和度（SpO（2））和其他指标被用作院内死亡率的预测指标。结果：在140例COVID-19相关肺炎患者中，72例（51.4%）为男性，中位年龄为60岁。SpO 2值小于或等于90%的患者年龄较大，男性患者更易患高血压，与SpO 2值大于90%的患者相比，更易出现呼吸困难。总体而言，36例患者（25.7%）在中位14天随访后住院期间死亡。吸氧后较高的SpO（2）水平与死亡率降低相关，与年龄和性别无关（每1 U SpO（2）的风险比为0.93; 95%CI为0.91 - 0.95; P
Objective: To identify markers associated with in-hospital death in patients with coronavirus disease 2019 (COVID-19)-associated pneumonia. Patients and Methods: A retrospective cohort study was conducted of 140 patients with moderate to critical COVID-19-associated pneumonia requiring oxygen supplementation admitted to the hospital from January 28, 2020, through February 28, 2020, and followed up through March 13, 2020, in Union Hospital, Wuhan, China. Oxygen saturation (SpO(2) ) and other measures were tested as pre-dictors of in-hospital mortality in survival analysis. Results: Of 140 patients with COVID-19-associated pneumonia, 72 (51.4%) were men, with a median age of 60 years. Patients with SpO 2 values of 90% or less were older and were more likely to be men, to have hypertension, and to present with dyspnea than those with SpO(2) values greater than 90%. Overall, 36 patients (25.7%) died during hospitalization after median 14-day follow-up. Higher SpO(2) levels after oxygen supplementation were associated with reduced mortality independently of age and sex (hazard ratio per 1-U SpO(2) , 0.93; 95% CI, 0.91 to 0.95; P