Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
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干扰素诱导的跨膜蛋白3基因变异rs12252-C与中国人的严重流感有关
DOI：
10.1038/ncomms2433
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
SNP rs 12252-C等位基因改变了干扰素诱导的跨膜蛋白3的功能，增加了高加索人流感病毒感染的疾病严重程度，但该等位基因很罕见。然而，rs 12252-C在汉族人中更为常见。在这里，我们报告说，CC基因型被发现在69%的中国患者与严重的大流行性甲型H1N1/09流感病毒感染相比，25%的轻度感染。具体而言，CC基因型估计比CT和TT基因型赋予6倍更大的严重感染风险。更重要的是，由于风险基因型发生频率如此之高，其效应转化为研究的中国人群中严重感染的54.3%的人群归因风险，而北方欧洲人为5.4%。因此，干扰素诱导的跨膜蛋白-3基因变异可能对中国和中国人的流感流行病学有很大影响。
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
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影响因子：
64.8
作者：
Everitt, Aaron R.;Clare, Simon;Pertel, Thomas;John, Sinu P.;Wash, Rachael S.;Smith, Sarah E.;Chin, Christopher R.;Feeley, Eric M.;Sims, Jennifer S.;Adams, David J.;Wise, Helen M.;Kane, Leanne;Goulding, David;Digard, Paul;Anttila, Verneri;Baillie, J. Kenneth;Walsh, Tim S.;Hume, David A.;Palotie, Aarno;Xue, Yali;Colonna, Vincenza;Tyler-Smith, Chris;Dunning, Jake;Gordon, Stephen B.;Smyth, Rosalind L.;Openshaw, Peter J.;Dougan, Gordon;Brass, Abraham L.;Kellam, Paul
通讯作者：
Kellam, Paul
影响因子：
6.7
作者：
Huang IC;Bailey CC;Weyer JL;Radoshitzky SR;Becker MM;Chiang JJ;Brass AL;Ahmed AA;Chi X;Dong L;Longobardi LE;Boltz D;Kuhn JH;Elledge SJ;Bavari S;Denison MR;Choe H;Farzan M
通讯作者：
Farzan M
影响因子：
64.8
作者：
Schoggins, John W.;Wilson, Sam J.;Panis, Maryline;Murphy, Mary Y.;Jones, Christopher T.;Bieniasz, Paul;Rice, Charles M.
通讯作者：
Rice, Charles M.
影响因子：
6.7
作者：
Feeley EM;Sims JS;John SP;Chin CR;Pertel T;Chen LM;Gaiha GD;Ryan BJ;Donis RO;Elledge SJ;Brass AL
通讯作者：
Brass AL
影响因子：
64.5
作者：
Brass AL;Huang IC;Benita Y;John SP;Krishnan MN;Feeley EM;Ryan BJ;Weyer JL;van der Weyden L;Fikrig E;Adams DJ;Xavier RJ;Farzan M;Elledge SJ
通讯作者：
Elledge SJ