ASSOCIATION BETWEEN HIGH-LEVELS OF EXPRESSION OF THE TRK GENE AND FAVORABLE OUTCOME IN HUMAN NEUROBLASTOMA
ASSOCIATION BETWEEN HIGH-LEVELS OF EXPRESSION OF THE TRK GENE AND FAVORABLE OUTCOME IN HUMAN NEUROBLASTOMA
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DOI：
10.1056/nejm199303253281205
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发表时间：
1993-03-25
影响因子：
158.5
通讯作者：
BRODEUR, GM
中科院分区：
文献类型：
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作者：
NAKAGAWARA, A;ARIMANAKAGAWARA, M;BRODEUR, GM
背景和方法。神经生长因子受体在一些神经母细胞瘤中表达，其中其主要成分由TRK原癌基因编码。为了确定TRK信使RNA在神经母细胞瘤中的表达与其他临床和实验室变量的关系，我们研究了77例患者的冷冻肿瘤样本。此外，我们检测了两个表达TRK的原发性神经母细胞瘤对神经生长因子的反应性。TRK表达与肿瘤分期（I、II、IVS与III、IV期）、年龄（
Background and Methods. The nerve growth factor receptor is expressed in some neuroblastomas, in which its primary component is encoded by the TRK proto-oncogene. To determine the relation of the expression of TRK messenger RNA in neuroblastomas to other clinical and laboratory variables, we studied frozen tumor samples from 77 patients. In addition, we tested two primary neuroblastomas that expressed TRK for responsiveness to nerve growth factor.Results. TRK expression strongly correlated with favorable tumor stage (I, II, and IVS vs. III and IV), younger age (