Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis
Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis
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两种酚酸口服香蒲花粉后对正常大鼠和急性寒血瘀证大鼠的药代动力学比较
DOI：
10.1002/bmc.4028
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发表时间：
2017
影响因子：
1.8
通讯作者：
刘晓秋
中科院分区：
文献类型：
--
作者：
潘英妮;张文杰;张薇;白雪薇;任舒蒙;郑江;王冬梅;刘晓秋
香蒲花粉，香蒲的干燥花粉，香蒲（TyphaorientalisPresl）为香蒲科（Typhaaceae）香蒲属（TyphaorientalisPresl）植物，具有活血化瘀的功效。本研究的目的是建立测定大鼠血浆中对羟基苯甲酸和香草酸的超高效液相色谱法，比较其在正常大鼠和急性寒血瘀证大鼠体内的药代动力学，并进一步考察不同剂量口服给药的影响。simultaneously.in药代动力学参数表明，两种酚酸在寒血瘀证大鼠体内的生物利用度均高于正常大鼠，药时曲线下面积较大，平均滞留时间较长，且高剂量口服给药组在血瘀证大鼠体内的生物利用度高于正常大鼠。这些结果提示，健康状况的改变可改变两种酚酸在体内的吸收和消除，病理状态下的药代动力学研究可为临床合理用药提供重要信息。
Typhae Pollen, dried pollen of Typha angustifolia L., Typha orientalis Presl or other plants of the.same genus (Typhaeceae), has the effect of activating the circulation to cure blood stasis in traditional.Chinese Medicine. The purpose of this study was to set up an ultra‐high performance liquid.chromatography method that could determine p‐hydroxybenzoic acid and vanillic acid simultaneously.in rat plasma, and to compare their pharmacokinetics in normal rats and rats with acute.cold blood stasis, and further to investigate the influence of different dosages of oral administration..The pharmacokinetic parameters obtained showed that both of the phenolic acids had a.higher bioavailability in rats with cold blood stasis than that in normal rats with a higher area.under the concentration–time curve and longer mean residence time, and the high dose oral.administration group had a higher capacity in blood stasis rats than in normal rats. These results.reminded us that changes in health condition could alter the absorption and elimination of both.phenolic acids in vivo, and the pharmacokinetic study under pathological conditions provides.important information for more rational drug use in clinical situations.