Circadian rhythms influence hematopoietic stem cells.
Circadian rhythms influence hematopoietic stem cells.
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DOI：
10.1097/moh.0b013e32832bd0f5
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发表时间：
2009-07
影响因子：
3.2
通讯作者：
Frenette PS
中科院分区：
文献类型：
--
作者：
Méndez-Ferrer S;Chow A;Merad M;Frenette PS
造血在骨髓（BM）中通过微环境、来自循环的可溶性因子和来自自主神经系统的神经输入而受到严格调节。大多数生理过程不是统一的，而是根据一天中的时间而变化。越来越多的证据表明，生物节律在造血干细胞（HSC）的运输及其增殖和分化能力的影响。最近的证据支持的作用，交感神经系统（SNS）的调节HSC的行为，直接和通过支持基质细胞。此外，SNS将昼夜节律信息从大脑中的中央起搏器（视交叉上核（SCN））转换到BM微环境，指导造血和HSC迁移中的昼夜节律振荡。HSC运输和造血不能逃脱控制大多数生理过程的昼夜节律调节。在临床上，干细胞收获或输注的时机可能分别影响产量或植入，并可能导致更好的治疗结果。
Hematopoiesis is tightly regulated in the bone marrow (BM) through the microenvironment, soluble factors from the circulation and neural inputs from the autonomic nervous system. Most physiological processes are not uniform but rather vary according to the time of day. There is increasing evidence showing the impact of biological rhythms in the traffic of hematopoietic stem cells (HSC) and their proliferation and differentiation capacities. Recent evidence supports the role of the sympathetic nervous system (SNS) in the regulation of HSC behavior, both directly and through supporting stromal cells. In addition, the SNS transduces circadian information from the central pacemaker in the brain, the suprachiasmatic nucleus (SCN), to the BM microenvironment, directing circadian oscillations in hematopoiesis and HSC migration. HSC traffic and hematopoiesis do not escape the circadian regulation that control most physiological processes. Clinically, the timing of stem cell harvest or infusion may impact the yield or engraftment, respectively, and may result in better therapeutic outcomes.