The Lab-on-PCB framework for affordable, electronic-based point-of-care diagnostics: From design to manufacturing
The Lab-on-PCB framework for affordable, electronic-based point-of-care diagnostics: From design to manufacturing
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用于经济实惠、基于电子的护理点诊断的 PCB 实验室框架：从设计到制造
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
T. Prodromakis
中科院分区：
文献类型：
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作者：
N. Vasilakis;K. Papadimitriou;D. Evans;H. Morgan;T. Prodromakis
一种新型的印刷电路板上实验室（LoPCB）制造技术被证明用于开发低成本的电化学生物传感器，并结合微流体技术用于护理点（Point-of-Care）应用。对所开发的PCB架构进行了分析，详细介绍了拟议的LoPCB平台的三个开发领域，即微流体、生物传感器和电子器件。设计规则和潜在的制造限制进行了讨论，原型制造系统的表征的基础上。两个基于PCB的设备已被设计和制造，一个可变的和主动控制的稀释比和电化学生物传感器的微流体主动稀释器。所获得的结果证明了一个完整的LoPCB平台的可行性，其中所有三个隔室将共存和合作，提供了一个基于电子的电化学生物传感器系统。
A novel, Lab-on-Printed Circuit Board (LoPCB) manufacturing technology is demonstrated for the development of low-cost electrochemical biosensors combined with microfluidics for Point-of-Care (PoC) applications. An analysis of the developed PCB architecture is presented, detailing the three development areas of the proposed LoPCB platform, i.e. microfluidics, biosensors and electronics. Design rules and potential fabrication limitations are also discussed, based on the characterization of prototype fabricated systems. Two PCB-based devices have been designed and fabricated, a microfluidic active diluter with a variable and actively controlled dilution ratio and an electrochemical biosensor. The obtained results demonstrate the feasibility of a complete LoPCB platform, where all three compartments will co-exist and co-operate, providing an electronic-based PoC system for electrochemical biosensing.