MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
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DOI：
10.1136/jcp.51.9.667
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发表时间：
1998-09-01
影响因子：
3.4
通讯作者：
Bonsignore, G
中科院分区：
文献类型：
--
作者：
Guddo, F;Giatromanolaki, A;Bonsignore, G
目的-以化学方法检测肿瘤样本中的MUC 1（episialin）、表皮生长因子受体（EGFR）和c-erbB-2，因为已知MUC 1和c-erbB癌蛋白家族对细胞-细胞粘附系统的破坏在人类癌症转移的发展中是重要的。对单独手术治疗的小细胞肺癌进行episialin、EGFR和c-erbB-2检测。结果-episialin去极化表达与任何检测的组织病理学变量（T、N分期、分级、组织学、Ki 67增殖指数）无关。episialin与EGFR和c-erbB-2表达无相关性。生存分析显示，episialin去极化表达与不良预后相关（p = 0.003），尤其是在鳞状细胞病例中（p 0.0003）。上皮唾液酸蛋白表达定义了一组在淋巴结阳性类别中预后不良的患者（p = 0.003）。在多变量分析中，episialin是最重要的独立预后因素（p = 0.007），其次是N分期（p 0.04）。尽管在钙粘蛋白细胞-细胞粘附系统上具有相似的活性，但episialin和c-erbB癌蛋白的表达可能在不同的致病途径内被激活。
Aim-To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important in the development of metastasis in human cancers.Methods-93 tumour samples from patients with early stage non-small cell lung cancer treated with surgery alone were examined for episialin, EGFR, and c-erbB-2.Results-Episialin depolarised expression did not correlate with any of the histopathological variables examined (T,N stage, grade, histology, Ki67 proliferation index). No correlation was observed between episialin and EGFR or c-erbB-2 expression. Survival analysis showed that episialin depolarised expression correlated with poor prognosis (p = 0.003), especially in squamous cell cases (p 0.0003). Episialin expression defined a group of patients with poor prognosis in the node positive category (p = 0.003). In multivariate analysis episialin was the most significant independent prognostic factor (p = 0.007), followed by N stage (p 0.04).Conclusions-Depolarised expression of episialin is associated with poor outcome in early stage non-small cell lung cancer. Despite the similar activity on the cadherin cell-cell adhesion system, the expression of episialin and c-erbB oncoproteins is likely to be activated within different pathogenic pathways.