Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.
Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.
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DOI：
10.1186/1749-8546-6-31
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发表时间：
2011-08-23
期刊：
影响因子：
4.9
通讯作者：
Batra SK
中科院分区：
文献类型：
--
作者：
Mimeault M;Batra SK
姜黄素由于其对各种类型的侵袭性和复发性癌症的化学预防、抗肿瘤、放射增敏和化学增敏活性而在临床肿瘤学的治疗武器库中引起了极大的关注。这些恶性肿瘤包括白血病、淋巴瘤、多发性骨髓瘤、脑癌、黑素瘤和皮肤癌、肺癌、前列腺癌、乳腺癌、卵巢癌、肝癌、胃肠癌、胰腺癌和结肠直肠上皮癌。姜黄素通过多种分子机制介导其对癌细胞（包括癌干/祖细胞及其后代）的抗增殖、抗侵袭和凋亡作用。姜黄素抑制的致癌途径包括表皮生长因子受体（EGFR和erbB 2）、音刺猬（SHH）/GLI和Wnt/β-连环蛋白以及下游信号传导元件如Akt、核因子-κ B（NF-κB）和信号转导和转录激活因子（STAT）。相反，姜黄素的高代谢不稳定性和差的全身生物利用度限制了其在人体中的治疗功效。具有巨大治疗意义的是，将姜黄素的合成类似物或基于纳米技术的制剂单独或与其他抗癌药物组合选择性递送至肿瘤，可以改善其针对癌症进展和复发的化学预防和化学治疗功效。新型姜黄素制剂也可用于逆转耐药性，根除总癌细胞团，并改善目前抗激素和化疗治疗对各种侵袭性和致死性癌症患者的抗癌功效。
Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities against various types of aggressive and recurrent cancers. These malignancies include leukemias, lymphomas, multiple myeloma, brain cancer, melanoma and skin, lung, prostate, breast, ovarian, liver, gastrointestinal, pancreatic and colorectal epithelial cancers. Curcumin mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer cells, including cancer stem/progenitor cells and their progenies, through multiple molecular mechanisms. The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/β-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-κB) and signal transducers and activators of transcription (STATs). In counterbalance, the high metabolic instability and poor systemic bioavailability of curcumin limit its therapeutic efficacy in human. Of great therapeutic interest, the selective delivery of synthetic analogs or nanotechnology-based formulations of curcumin to tumors, alone or in combination with other anticancer drugs, may improve their chemopreventive and chemotherapeutic efficacies against cancer progression and relapse. Novel curcumin formulations may also be used to reverse drug resistance, eradicate the total cancer cell mass and improve the anticarcinogenic efficacy of the current anti-hormonal and chemotherapeutic treatments for patients with various aggressive and lethal cancers.
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影响因子：
2.3
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通讯作者：
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