Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin
Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin
复制标题
口服乳源性磷脂可抑制急性皮肤干燥小鼠模型中皮肤神经纤维渗入表皮
DOI：
10.1111/ced.13207
复制
发表时间：
2017
影响因子：
4.1
通讯作者：
Takamori K
中科院分区：
文献类型：
--
作者：
Sakaguchi A;Kamata Y;Takahashi N;Matsuda H;Kosaka R;Umehara Y;Ogawa H;Tominaga M;Takamori K
瘙痒性干燥皮肤的表皮内神经纤维密度高于健康皮肤，这表明表皮神经过度支配至少部分参与了周围性瘙痒致敏。我们研究了口服乳源性磷脂（MPLs）是否会抑制干性皮肤小鼠模型的表皮高神经支配。我们发现MPL组表皮内神经纤维的数量明显低于对照组。口服MPL组表皮神经生长因子（NGF）表达水平显著降低，而神经排斥因子信号素（Sema）3A表达水平升高。上述结果表明，饲粮中添加多磺酸可通过降低表皮NGF水平和增加Sema3A水平来减弱神经纤维向表皮的渗透。因此，饮食中的多磺酸可能通过减少表皮内神经纤维密度，在预防和/或减轻皮肤干燥引起的瘙痒方面具有有益作用。
The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk‐derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Expression of nerve growth factor (NGF) levels in the epidermis was significantly decreased by oral administration of MPLs, whereas expression of semaphorin (Sema)3A, a nerve repulsion factor, was increased in the MPL group. These results suggest that dietary MPLs attenuate the penetration of nerve fibres into the epidermis by reducing epidermal NGF levels and increasing Sema3A level. Thus, dietary MPLs may have beneficial effects in the prevention and/or alleviation of dry skin‐induced itch by reducing intraepidermal nerve fibre density.