The actin-related proteins
The actin-related proteins
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DOI：
10.1016/s0955-0674(96)80045-7
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发表时间：
1996-02-01
影响因子：
7.5
通讯作者：
Mooseker, MS
中科院分区：
文献类型：
--
作者：
Frankel, S;Mooseker, MS
在过去的三年中发现了一个蛋白质家族，其成员与肌动蛋白具有明确的序列同源性，但在结构和功能上与肌动蛋白不同。这个家族的成员被称为肌动蛋白相关蛋白（arps），其数量正在迅速增加。Arps只是一个更大的超家族的一个分支，该超家族包括肌动蛋白、hsp/hsc 70、糖激酶和来自细菌的几种细胞周期蛋白。该超家族的存在已从三级结构数据推断。在arp的情况下，它们的鉴定和分类是基于一级结构数据。将arps置于功能背景下是一个缓慢的过程，尽管遗传和生化分析在一些情况下是一致的。在过去的一年中，不同的arp已经与肌动蛋白丝（arp 2和arp 3），微管（arp 1）和染色质结构元件（arp 4和arp 6）介导的功能有关。
family of proteins has been discovered over the past three years whose members have clear sequence homology to actin but are distinguished from actin by their structural and functional diversity. The ranks of this family, whose members are known as the actin-related proteins (arps), are expanding rapidly. Arps are but one branch of a larger superfamily which includes the actins, hsp/hsc70s, sugar kinases and several cell cycle proteins from bacteria. The existence of the superfamily has been inferred from tertiary structural data. In the case of the arps, their identification and classification has been based upon primary structural data. Placing the arps in a functional context is proving a slower process, although genetic and biochemical analyses are converging in several cases. In the past year, different arps have been linked to functions mediated by actin filaments (arp2 and arp3), microtubules (arp1) and the structural elements of chromatin (arp4 and arp6).