A COMPARATIVE-STUDY OF MANGANESE MESO-SULFONATOPHENYL PORPHYRINS - CONTRAST-ENHANCING AGENTS FOR TUMORS
A COMPARATIVE-STUDY OF MANGANESE MESO-SULFONATOPHENYL PORPHYRINS - CONTRAST-ENHANCING AGENTS FOR TUMORS
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DOI：
10.1016/0730-725x(90)90097-l
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发表时间：
1990-01-01
影响因子：
2.5
通讯作者：
ALLETTO, JJ
中科院分区：
文献类型：
--
作者：
FIEL, RJ;MUSSER, DA;ALLETTO, JJ
制备了四种锰中磺基卟啉，并对其作为肿瘤特异性MRI增强剂在小鼠乳腺癌皮下植入物（SMT-F）中的潜力进行了表征和研究。注射后24小时，三磺化四苯基卟啉MnTPPS3表现出最有利的生物分布、肿瘤浓度和肿瘤弛豫度。成像实验显示，肿瘤形态的时间依赖性描绘发生在MnTPPS3的反应中，似乎与肿瘤的坏死区域相关。
Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary cacinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: biodistribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor.