ROLE OF LIVER IN REGULATING DISTRIBUTION AND EXCRETION OF MANGANESE
ROLE OF LIVER IN REGULATING DISTRIBUTION AND EXCRETION OF MANGANESE
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DOI：
10.1152/ajplegacy.1966.211.1.211
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发表时间：
1966-01-01
影响因子：
--
通讯作者：
COTZIAS, GC
中科院分区：
文献类型：
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作者：
PAPAVASILIOU, PS;MILLER, ST;COTZIAS, GC
直肠梗阻废除全身损失锰54在锰负荷和黄疸大鼠。胆管阻塞只减少了放射性同位素的排泄，证明了几种胃肠道途径排泄锰。如果经门静脉注射同位素，则排泄非常快，但随后胆汁结扎的效果增强。此外，胆道结扎引起的上升，然后在肝脏中的Mn54的浓度下降，而自然金属（Mn55）的增加。辅助实验将这些现象与金属的吸收和快速再排泄联系起来。这一肠肝循环参与了锰排泄的调节。常规的加速排泄后，中等负荷与锰被取消阻塞胆管。如果胆汁结扎的动物体内金属超载，就可以诱导加速。数据的总和表明，胆汁形成构成了在普通条件下的主要调节途径，但在超负荷条件下，辅助胃肠道途径参与。
Rectal obstruction abolished the total-body loss of Mn54 in both manganese-loaded and jaundiced rats. Bile duct obstruction only diminished the excretion of the radioisotope, proving that several gastrointestinal routes excrete manganese. Excretion was exceedingly fast if the isotope was injected intraportally, but then the effect of bile ligation became enhanced. Furthermore, biliary ligation induced a rise followed by a decline in the concentration of Mn54 in the liver, whereas that of the natural metal (Mn55) increased. Ancillary experimentation linked these phenomena to absorption and rapid reexcretion of the metal. This enterohepatic circulation participated in regulating the excretion of Mn. The customary acceleration of excretion following moderate loads with Mn was abolished by blocking the bile duct. Acceleration could be induced in bile-ligated animals provided they were overloaded with metal. The sum of the data indicated that bile formation constitutes the main regulatory route under ordinary conditions, but, under conditions of overloading, auxiliary gastrointestinal routes participate.