Seven new guanacastane-type diterpenoids from the fungus Verticillium dahliae
Seven new guanacastane-type diterpenoids from the fungus Verticillium dahliae
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来自真菌大丽黄萎病的七种新瓜那卡烷型二萜类化合物
DOI：
10.1016/j.fitote.2019.01.009
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发表时间：
2019-03-01
期刊：
影响因子：
3.4
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
--
作者：
Zhang, Hong;Yang, Ming-Hua;Kong, Ling-Yi
Seven new guanacastane-type diterpenoids, namely dahlianes E-K (1-7), and three known ones (8-10) were isolated from the cultures of the fungus Verticillium dahlias. Their structures were established by extensive spectroscopic data analysis along with Rh-2(OCOCF3)(4)- and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) experiment. Dahliane G showed an 80-fold potentiation effect on the sensitization of doxorubicin at the concentration of 15 mu M when screening the reversal activity on doxorubicin-resistant human breast cancer cells (MCF-7/DOX).
