Effect of acute hypoxia on QT rate dependence and corrected QT interval in healthy subjects
Effect of acute hypoxia on QT rate dependence and corrected QT interval in healthy subjects
复制标题
DOI：
10.1016/s0002-9149(03)00040-7
复制
发表时间：
2003-04-01
影响因子：
2.8
通讯作者：
Barthélémy, JC
中科院分区：
文献类型：
--
作者：
Roche, F;Reynaud, C;Barthélémy, JC
11例健康志愿者，男6例，女5例，年龄29~13岁，身高174 8 cm，体重679 kg。没有志愿者有心血管或代谢性疾病的病史，也没有系统性高血压。没有患者参与体育锻炼计划或具有登山专业经验。体格检查和基本标准12导联心电图正常。在被充分告知这项研究的性质并给予同意后，每个受试者进入海平面(气压723托，环境温度28摄氏度)的安静房间。在15分钟仰卧休息后，受试者被要求遵循规则的呼吸模式。连续测量血压、心率(HR)和血氧饱和度。然后，受试者被置于低氧常压条件下，吸入低氧含量(吸入氧浓度11%)的混合气体15分钟，模拟海拔4800m。然后受试者在缺氧结束后立即经历20分钟的恢复期。从Holter记录中分析QT的方法此前已有报道。用计算机辅助的方法(加利福尼亚州欧文的Del Mar)分析1，2个Holter磁带的QT间期。采用体表心电图V5导联位置对应的Holter通道。对波形分析仪进行编程以比较QRS波群；在记录开始时定义并验证参考波群。T波的终点被定义为T波的下斜率越过等电线的点。操作员对分析周期视而不见，监视分析并纠正QT中明显的计算机错误
We studied 11 healthy volunteers (6 men and 5 women, aged 29 13 years, height 174 8 cm, body weight 67 9 kg). No volunteer had a history of cardiovascular or metabolic diseases or had systemic hypertension. No patient was engaged in athletic exercise programs or had professional experience in mountain climbing. Physical examinations and basal standard 12-lead electrocardiograms were normal. After being fully informed of the nature of the study and after giving consent, each subject entered a quiet room at sea level (barometric pressure 723 Torr, ambient temperature 28 C). After a 15-minute supine resting period, subjects were asked to follow a regular breathing pattern. Blood pressure, heart rate (HR), and oxygen saturation were continuously measured. Then, subjects were placed in hypoxic normobaric conditions using inhalation of a gas mixture with low oxygen content (inspired oxygen concentration 11%) during 15 minutes, which simulates an altitude of 4,800 m. Subjects then went through a recovery period of 20 minutes immediately after the end of exposure to hypoxia. Methods for QT analysis from Holter recordings have been previously reported. 1, 2 Holter tapes were analyzed for QT intervals by a computerized-assisted method (Del Mar, Irvine, California). The Holter channel corresponding to the lead V5 position on the surface electrocardiogram was used. The waveform analyzer was programmed to compare QRS complexes; the reference complex was defined and validated at the beginning of the recording. The end of the T wave was defined as the point at which the downslope of the T wave crossed the isoelectric line. The operator, who was blinded to the analyzed period, monitored the analysis and rectified obvious computer errors in QT