Hepatoprotective Iridoid Glycosides from the Roots of Rehmannia glutinosa
Hepatoprotective Iridoid Glycosides from the Roots of Rehmannia glutinosa
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DOI：
10.1021/np300509z
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发表时间：
2012-09-01
影响因子：
5.1
通讯作者：
Yu, De-Quan
中科院分区：
文献类型：
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作者：
Liu, Yan-Fei;Liang, Dong;Yu, De-Quan
从紫茎泽兰根中分得11个新的环烯醚萜苷类化合物，即紫茎泽兰苷A-K（1-11），以及20个已知的类似物。根据光谱数据分析和化学证据确定了这些化合物的结构。此外，在体外试验中，化合物3、7和9-11（10 μ M）对D-半乳糖胺诱导的HL-7702细胞损伤表现出中等的肝保护活性。
Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 mu M) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.