Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
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DOI：
10.1161/strokeaha.115.009598
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发表时间：
2015-09-01
期刊：
影响因子：
8.3
通讯作者：
Ibanez, Agustin
中科院分区：
文献类型：
--
作者：
Garcia-Cordero, Indira;Sedeno, Lucas;Ibanez, Agustin
背景和目的：中风和神经退行性变会导致严重的脑损伤和认知障碍，特别是当岛叶皮层受损时。这项研究首次探索了这两种原因是否会不同地改变岛叶皮层的连接模式。方法：收集岛状脑卒中患者、行为变异性额颞叶痴呆患者和健康对照者的静息状态-功能磁共振成像数据。通过相关函数分析对3组数据进行评价。具体来说，我们比较了岛叶皮层体素欧几里得距离的连通性下降。结果：相对于对照组，脑卒中患者表现出更快的连通性衰退，作为距离的函数（低连通性）。相比之下，行为变异额颞叶痴呆组在相邻体素之间表现出显著的超连通性。两组患者均表现出整体连通性低下。在没有缺血或神经退行性变的体积和功能可比较的区域，没有观察到组间差异。结论：脑缺血和神经退行性变对功能性岛叶皮质连通性的影响不同，可能是由于每种疾病的病因特异性病理生理机制不同。这些发现具有重要的临床和理论意义。
Background and Purpose-Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex.Methods-Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex.Results-Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration.Conclusions-Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.