Antibody-Mediated Lung Transplant Rejection.
Antibody-Mediated Lung Transplant Rejection.
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DOI：
10.1007/s13665-012-0019-8
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Hachem R
中科院分区：
文献类型：
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作者：
Hachem R
肺移植后抗体介导的排斥反应仍然是个谜。然而，过去几年的新证据表明，体液免疫在同种异体移植排斥中发挥着重要作用。事实上，移植后供体特异性抗体的产生已被确定为急性细胞排斥和闭塞性细支气管炎综合征的独立危险因素。此外，已经报道了抗体介导的急性排斥反应导致严重同种异体移植物功能障碍的病例，这表明抗体可以直接损伤同种异体移植物。然而，抗体介导的排斥反应的发生率和死亡人数尚不清楚，因为没有广泛接受的定义，并且某些病例可能未被识别。显然，体液免疫已成为研究和临床调查的重要领域。
Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndrome. Furthermore, cases of acute antibody-mediated rejection resulting in severe allograft dysfunction have been reported, and these demonstrate that antibodies can directly injure the allograft. However, the incidence and toll of antibody-mediated rejection are unknown because there is no widely accepted definition and some cases may be unrecognized. Clearly, humoral immunity has become an important area for research and clinical investigation.