EXPRESSION OF E-CADHERIN (E-CD) AS RELATED TO OTHER PROGNOSTIC FACTORS AND SURVIVAL IN BREAST-CANCER
EXPRESSION OF E-CADHERIN (E-CD) AS RELATED TO OTHER PROGNOSTIC FACTORS AND SURVIVAL IN BREAST-CANCER
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DOI：
10.1002/path.1711740206
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发表时间：
1994-10-01
影响因子：
7.3
通讯作者：
SYRJANEN, K
中科院分区：
文献类型：
--
作者：
LIPPONEN, P;SAARELAINEN, E;SYRJANEN, K
A series of 208 breast cancer biopsies were analysed immunohistochemically for expression of E-cadherin (E-CD). Altogether, 72 per cent of the tumours showed E-CD positivity in over 50 per cent of cells, the staining being heterogeneous in nearly all tumours. In only 16 per cent of ductal carcinomas was positive staining seen in less than 1 per cent of cells. Expression of E-CD was not related to tumour diameter, nodal status, metastasis at diagnosis, histologicaI grade, DNA ploidy, S-phase fraction, nuclear area, mitotic frequency, or PR content. There was a significant relationship between expression of E-CD, histological type (P=0.01), the proportion of intraductal growth (P=0.008), the density of tumour-infiltrating lymphocytes (P=0.0007), ER content (P=0.012), and morphometric nuclear factors (P
