Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment.

Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment.
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DOI:
10.1126/science.1195870
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发表时间:
2011-01-07
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Fiser J
Fiser J
中科院分区:
其他
文献类型:
--
作者:
Berkes P;Orbán G;Lengyel M;Fiser J

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大脑维护其环境的内部模型,以解释感觉输入并准备行动。虽然行为研究表明,这些内部模型对环境的统计数据是最佳适应的,但这种适应的神经基础尚不清楚。使用感觉皮层处理的贝叶斯模型,我们将刺激诱发和自发活动与内部模型中的推断和先前预期相关联,并预测如果该模型是统计上最优的,它们应该匹配。为了验证这一预测,我们分析了清醒雪貂在发育过程中的视觉皮质活动。自发活动和诱发活动之间的相似性随着年龄的增长而增加,并且特定于自然场景引起的反应。这表明内部模型在神经水平上逐渐适应自然刺激的统计。
The brain maintains internal models of its environment to interpret sensory inputs and prepare actions. While behavioral studies demonstrated that these internal models are optimally adapted to the statistics of the environment, the neural underpinning of this adaptation is unknown. Using a Bayesian model of sensory cortical processing, we related stimulus-evoked and spontaneous activities to inferences and prior expectations in an internal model and predicted that they should match if the model is statistically optimal. To test this prediction, we analyzed visual cortical activity of awake ferrets during development. Similarity between spontaneous and evoked activities increased with age and was specific to responses evoked by natural scenes. This demonstrates the progressive adaptation of internal models to the statistics of natural stimuli at the neural level.
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